The TOXEM laboratory, specialized in medical genotoxicity and genetics, was commissioned by HBN to determine the capacity of the telomeric DNA product© to act as a “molecular crutch” allowing the TP53 protein (tumor suppressor gene) to recover its functionalities (transcriptional activity, regulation of the cell cycle, etc.), the critical loss of information otherwise inducing a mutation characteristic of carcinogenesis.
Telomeractive DNA© is capable of partially restoring transcriptional activity on certain mutated TP53 proteins. This restoration potentially allows the mutated protein to play an important role in maintaining genome integrity (DNA restoration, apoptosis – elimination of cells that present irreparable DNA damage – damaged telomeres) and therefore a role in preventing tumor transformation.
